Check out Flipping Typical ("A way to explore the popular typefaces you have on your computer") to get an on-screen comparison of a bunch of different fonts that you have installed. The site uses some fancy tricks to determine whether you have certain fonts installed and then displays an assortment of them. You can click on the font names and choose different fonts to customize which fonts show up in the comparison.
If you're like me and you find yourself scrolling through Font Book with custom text entered to see how it looks in various fonts...perhaps there is a use for this site. No guarantees.
Hat tip